![]() ![]() The drug has a broad influence on many types of bacteria, including some strains resistant to other antibiotics. It's commonly prescribed for burn victims or those with significant skin injuries. First approved by the FDA in 1973, Silvadene works by inhibiting the growth of bacteria that could infect an open wound. Silver sulfadiazine (the generic name for Silvadene) is a topical cream primarily used to prevent and treat infections in severe burns. On the other hand, Bactroban (mupirocin) inhibits bacterial protein synthesis by binding to an enzyme known as isoleucyl-tRNA synthetase, preventing bacteria from growing and multiplying – it's primarily used for minor skin infections like impetigo. Silvadene is a sulfa drug that directly kills bacteria while forming a protective barrier over the affected area, commonly used for treating serious burns. Each has a different mechanism of action but both serve to fight off bacterial invaders on the skin surface. Silvadene and Bactroban are two such drugs that are often prescribed for these conditions. Very rare (less than 0.For patients with skin infections or burns, certain topical antibiotics that prevent the growth of bacteria on the skin can help in managing symptoms and promoting healing. Hematologicįrequency not reported: Neutrophil count decreased, white blood cell depression, agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia DermatologicĬommon (1% to 10%): Pruritus, application site rash, eczema, contact dermatitisįrequency not reported: Skin necrosis, erythema multiforme, skin discoloration, burning sensation, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis Renal GeneralĪbsorption varies depending upon the percent of body surface area being treated and extent of tissue damage it is possible any adverse reaction associated with sulfonamides may occur. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Ĭheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Incidence not knownĪpplies to silver sulfadiazine topical: compounding powder, topical cream. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of silver sulfadiazine topical may occur that usually do not need medical attention. sores, ulcers, or white spots in the mouth or on the lips. ![]()
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